Abstract
IN earlier communications1–3 we reported the results of our investigations with acetylcholine and related substances. These led us to conclude that the acetyl group is activated primarily by an inductive influence of the quaternary nitrogen. This conclusion was based in large measure on the carbonyl stretching frequencies which were observed for acetylcholine and its homologues in ethanol, as well as on their rates of hydroxylaminolysis in water.
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References
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FELLMAN, J., FUJITA, T. Effects of Solvents on Acetylcholine Conformation. Nature 211, 848–850 (1966). https://doi.org/10.1038/211848b0
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DOI: https://doi.org/10.1038/211848b0
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