Abstract
THE successful transfer of nephrotoxic nephritis (Masugi's method) in rats to essentially healthy animals of the same inbred strain by parabiosis was described earlier1,2. In these experiments, transfer of rabbit antibody from the first into the second rat was excluded by the fluorescent antibody technique3. Recently, experiments were reported in which the so-called auto-immune nephrosis was also induced by par abiotic transfer4. Furthermore, this disease has been transferred by means of lymph node cells6. Nephrotoxic nephritis was “transferred” by peripheral white blood cells of nephritic donors6. It was assumed that blood lymphocytes were the immunologically responsible cells and caused the renal lesions in the recipient. It was considered that further investigations of the transfer of circulating lymphocytes obtained from a lymphatic vessel would prove whether or not this assumption was correct.
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FEDERLIN, K., LEINWEBER, W. & PFEIFFER, E. Transfer of Experimental Nephritis in Rats by means of Lymphatic Duct Lymphocytes. Nature 211, 1199–1200 (1966). https://doi.org/10.1038/2111199b0
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DOI: https://doi.org/10.1038/2111199b0
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