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Amyloidosis in Mice with a Transplantable Plasma Cell Tumour

Abstract

TRANSPLANTABLE plasma cell tumours of mice resemble human myelomatosis in the following features: morphology of the tumour cells1., production of globulins2, Bence Jones type of proteinuria3, osteolytic bone lesions4,5, and myeloma kidney3,6. All these features, however, are not present simultaneously in any one strain of neoplasm. Since systemic amyloidosis has been reported in 14 per cent of cases of human myelomatosis7, the presence of amyloid in mouse myelomatosis was investigated.

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LEHNER, T., ROSENOER, V. & TOPPING, N. Amyloidosis in Mice with a Transplantable Plasma Cell Tumour. Nature 209, 930–931 (1966). https://doi.org/10.1038/209930a0

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