Abstract
PROSTAGLANDINS (PG) were first identified chemically in 1960 by Bergström and his co-workers1–3 in extracts of sheep prostate gland, and since then they have been found in many other tissues. They are biologically active and stimulate or relax a variety of smooth muscle preparations4. Recently, evidence has been obtained for an action on the central nervous system following intraventricular or intravenous injection in small doses5,6. PGF2α has been isolated from bovine brain7 and evidence has been obtained that PGE1 or PGE2 is released from the cerebral cortex into a superfusate following afferent or cortical stimulation8. Krnjević, however, was unable to detect any action of PGE1 on cerebral cortical neurones when it was released by iontophoresis9.
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AVANZINO, G., BRADLEY, P. & WOLSTENCROFT, J. Excitatory Action of Prostaglandin E1 Brain-stem Neurones. Nature 209, 87–88 (1966). https://doi.org/10.1038/209087a0
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DOI: https://doi.org/10.1038/209087a0
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