Abstract
LABELLED nutrients have become indispensable in research since they facilitate investigations which otherwise would be impossible or extremely difficult. As an example may be mentioned Hoekstra's1 investigations of zinc metabolism, in which he used the general method suggested by Cotzias et al.2. Zinc-65 retention in rats was determined by whole-body counting. Once the zinc-65 had been absorbed from the digestive tract it was handled similarly to injected zinc-65. The percentage absorption of orally-given zinc-65 was calculated by extrapolating the linear part of the retention curves (plotted on a logarithmic scale versus time) back to zero time and adding the increment representing the non-linear portion of the injected zinc-65 curve.
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References
Hoekstra, W. G., Fed. Proc., 23, 1068 (1964).
Cotzias, G. C., Borg, D. C., and Selleck, B., Amer. J. Physiol., 202, 359 (1962).
Svensson, S. A., Nature, 193, 796 (1962).
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SVENSSON, S. Two Principles for Absorption Determinations using Isotope-labelled Nutrients. Nature 206, 732–733 (1965). https://doi.org/10.1038/206732a0
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DOI: https://doi.org/10.1038/206732a0
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