Abstract
A PREVIOUS study of stem-cell response to erythropoietin in the polycythaemic mouse after 150 rads showed an initial depression to values between 5 and 15 per cent of unirradiated controls1. Gurney2, however, in an earlier publication, reported an erythropoietin response after a single dose of 150 rads of about 30–40 per cent of control. The experiments were similar except for the dose of erythropoietin used: in our experiments about 0.5 unit (M.R.C. Standard ‘A’)3 and in Gurney's 6 units Armour Company erythropoietin (≍ 10 units M.R.C. Standard ‘A’). We therefore decided to investigate whether or not the dose of erythropoietin influences the apparent radiation effect in this system.
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References
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PORTEOUS, D., TSO, S., HIRASHIMA, K. et al. Modification of X-ray Survival Curves of Stem-cells by Different Doses of Erythropoietin. Nature 206, 204–206 (1965). https://doi.org/10.1038/206204b0
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DOI: https://doi.org/10.1038/206204b0
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