Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

A Radio-enzymatic Assay for Folic Acid

Abstract

MANY important physiological substances such as some of the hormones, vitamins and metabolic substrates are present in both animals and humans in minute concentration; that is, at levels not detectable by usual physico-chemical procedures. This has necessitated the application of perhaps more sensitive, but usually less specific, biological assays. The results of such assays are often variable from laboratory to laboratory, frequently lack specificity, and usually require special technical skills.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Yalow, R. S., and Berson, S. A., J. Clin. Invest., 39, 1173 (1960).

    Article  Google Scholar 

  2. Utiger, R. D., Parker, M. L., and Daughaday, W. H., J. Clin. Invest., 41, 254 (1962).

    Article  CAS  Google Scholar 

  3. Rothenberg, S. P., J. Clin. Invest., 42, 1391 (1963).

    Article  CAS  Google Scholar 

  4. Futterman, S., J. Biol Chem., 228, 1031 (1958).

    Google Scholar 

  5. Zakrzewski, S. F., and Nichol, C. A., J. Biol. Chem., 235, 2984 (1960).

    CAS  PubMed  Google Scholar 

  6. Zakrzewski, S. F., J. Biol. Chem., 235, 1776 (1960).

    CAS  PubMed  Google Scholar 

  7. Mathews, C. K., in Enzymatic Interconversions of Folid Acid, Dihydrofolic Acid, and Tetrahydrofolic Acid, edit. by Mathews, C. K. (University Microfilms, 1962).

    Google Scholar 

  8. Zakrzewski, S. F., J. Biol. Chem., 235, 1780 (1960).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

ROTHENBERG, S. A Radio-enzymatic Assay for Folic Acid. Nature 206, 1154–1156 (1965). https://doi.org/10.1038/2061154a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/2061154a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing