Abstract
THE neuropathological effects of dosing dogs over a prolonged period with some monoamine oxidase inhibitors have already been described by us1. Two of the drugs, phenyl-iso-propyl hydrazine (‘JB 516’ or ‘Catron’) and tetra-hydronaphthyl hydrazine, produced strikingly focal bilateral degeneration of the inferior olives. Phenelzine (‘Nardil’) and indanyl carbethoxy hydrazine resulted in oedema and disintegration of sub-cortical myelin in the cerebrum, accompanied by microglial proliferation. It was suggested that perhaps a contributory cause of both types of lesion might be ascribed to elevated levels of brain serotonin.
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References
Palmer, A. C., and Noel, P. R. B., J. Path. Bact., 463 (1963).
Magee, P. M., Stoner, H. B., and Barnes, J. M., J. Path. Bact., 107 (1957).
Aleu, F. P., Katzman, R., and Terry, R. D., J. Neuropath., 403 (1963).
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PALMER, A., NOEL, P. Neuropathological Effects of Dosing Dogs with Isonicotinic Hydrazide and with its Methanosulphonate Derivative. Nature 205, 506–507 (1965). https://doi.org/10.1038/205506a0
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DOI: https://doi.org/10.1038/205506a0
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