Abstract
SUCCINYL choline was shown by Bovet et al.1 to be a neuromuscular blocking agent with a short duration of action. Its brief action is considered to be due to its hydrolysis by the pseudocholinesterase which is present in plasma. Hydrolysis occurs in two steps; first, succinyl monocholine is formed, then this compound is degraded to succinic acid and choline. The first step in the sequence proceeds faster than the second; further, succinyl monocholine has very little biological activity. The removal of the first choline moiety must consequently be considered as important in the biological inactivation of the compound.
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References
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Ho, A., FREEMAN, S. Anticholinesterase Activity of Tetrahydroaminacrine and Succinyl Choline Hydrolysis. Nature 205, 1118–1119 (1965). https://doi.org/10.1038/2051118a0
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DOI: https://doi.org/10.1038/2051118a0
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