Abstract
RECENT investigations1–3 demonstrated the value of metabolic inhibitors such as pyrethrin synergists as tools in the investigation of structure-activity relationships among the ‘cyclodiene’ type insecticides. Thus, the wide variations in toxicity to the housefly found in several groups of related cyclodienes were found to be reduced in the presence of the pyrethrin synergist ‘Sesamex’2, a phenomenon accompanied, in the case of compounds examined in vivo, by inhibition of metabolic conversions1,3.
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References
Brooks, G. T., and Harrison, A., Nature, 198, 1169 (1963).
Brooks, G. T., and Harrison, A., Biochem. Pharmacol., 13, 827 (1964).
Brooks, G. T., and Harrison, A., J. Insect Physiol., 10, 633 (1964).
Davidow, B., and Radomski, J. L., J. Pharmacol., 107, 259 (1953).
Perry, A. S., Mattson, A. M., and Buckner, A. J., J. Econ. Entomol., 51, 346 (1958).
Riemschneider, R., Wld. Rev. Pest Control, 2, 29 (1963).
Arvey Corporation, British patent 714,869 (1954).
Peri, C. A., Gazz. chim. Ital., 85, 1118 (1955).
Brooks, G. T., and Harrison, A., Biochem. J., 87, 5P (1963).
Brooks, G. T., and Harrison, A. (unpublished results).
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BROOKS, G., HARRISON, A. Structure-activity Relationships among Insecticidal Compounds derived from Chlordene. Nature 205, 1031–1032 (1965). https://doi.org/10.1038/2051031a0
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DOI: https://doi.org/10.1038/2051031a0
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