Abstract
ALL quantitative estimations of haptoglobin (Hp) are based on the measurement of its hæmoglobin- (Hb-) binding capacity and errors may arise from a decreased or inhibited affinity of haptoglobin for hæmoglobin. The results of the peroxidase activity method4 may be influenced by serum factors inhibiting the peroxidase activity of the Hb-Hp complex. Robert, Bajic and Jayle1 have been able to show that certain chemical substances, such as heparin and glycin, will not only decrease the affinity of the haptoglobin and the peroxidase activity of the Hb-Hp complex but will also break down Hb-Hp complexes that have already formed. Analogously the influence of serum components on the Hb-Hp complex has been taken as a possible explanation for the often decreased serum Hp level in liver diseases2. The development of a method for direct determination of Hp was therefore of interest.
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KLUTHE, R., FAUL, J. & HEIMPEL, H. Quantitative Estimation of Human Serum Haptoglobins by an Immunological Method. Nature 205, 93–94 (1965). https://doi.org/10.1038/205093a0
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DOI: https://doi.org/10.1038/205093a0
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