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Radiation Inactivation of the Immunological and Biological Activities of Human Chorionic Gonadotropin

Nature volume 203, pages 979–980 (1964)Cite this article

Abstract

RADIATION of protein hormones or enzymes results in loss of activity. The rate of inactivation can be used to estimate the volume and weight of the active portion of the molecule if this rate is exponentially related to the dose of ionizing radiation and low-density ionizing radiation is used1. Previous investigations2 have demonstrated that the rate of loss of hormonal activity of human chorionic gonadotropin (HCG) exposed to a 2.0-MeV electron beam was exponential and was identical when measured by four bioassays: in intact immature rats by (1) uterine weight, and (2) ovarian hyperæmia responses; in hypophysectomized rats by (3) testes, and (4) prostate weight responses.

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Author notes

  1. WILLIAM E. PAUL: Clinical associate, Endocrinology Branch, National Cancer Institute.

  2. WILLIAM D. ODELL: Senior investigator, Endocrinology Branch, National Cancer Institute.

Authors and Affiliations

  1. Endocrinology Branch, National Cancer Institute, Bethesda, 14, Maryland

    WILLIAM E. PAUL & WILLIAM D. ODELL

Authors
  1. WILLIAM E. PAUL
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  2. WILLIAM D. ODELL
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PAUL, W., ODELL, W. Radiation Inactivation of the Immunological and Biological Activities of Human Chorionic Gonadotropin. Nature 203, 979–980 (1964). https://doi.org/10.1038/203979a0

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