Abstract
EARLY effects of carcinogenic hydrocarbons on the cell cycle and on deoxyribonucleic acid (DNA) synthesis have been noted by several authors. McCarter and Quastler1,2 found that 7,12-dimethylbenz[α]anthracene (DMBA) decreases the rate of incorporation of 3H-thymidine into DNA and prolongs the DNA synthetic phase of the generation cycle of mouse epidermal cells. Evensen3 found that 3-methylcholanthrene alters the proportion of epidermal cells labelled with 3H-thymidine in the hairless mouse. Jensen et al.4 reported a reduction in uptake of 3H-thymidine in various tissues of the mouse following the administration of DMBA, including some tissues in which tumours do not usually arise after treatment with this agent. Elgjo5 reported that 3-methylcholanthrene changes the mitotic phase of the cell cycle over an eleven-week period. We now report an early effect of DMBA on the synthesis of ribonucleic acid (RNA) in mouse skin.
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References
McCarter, J. A., and Quastler, H., Nature, 194, 873 (1961).
McCarter, J. A., and Quastler, H., Biochim. Biophys. Acta, 55, 552 (1962).
Evensen, A., Acta Pathol. Microbiol. Scand., Supp., 148, 43 (1961).
Jensen, E. V., Ford, E., and Huggins, C., Proc. U.S. Nat. Acad. Sci., 50, 454 (1963).
Elgjo, K., Nature, 200, 608 (1963).
McCarter, J. A., J. Nat. Cancer Inst., 17, 399 (1956).
Feinendegen, L. E., Bond, V. P., and Painter, R. B., Exp. Cell Res., 22, 381 (1961).
Harris, H., Biochem. J., 73, 362 (1962).
McMaster-Kaye, R., J. Histochem. Cytockem., 10, 154 (1962).
Watts, J. W., and Harris, H., Biochem. J., 72, 147 (1959).
Ball, J. K., and McCarter, J. A., Brit. J. Cancer, 14, 577 (1960).
Harris, H., Proc. Roy. Soc., B, 158, 79 (1963).
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SINCLAIR, N., McCARTER, J. Inhibition by a Carcinogenic Hydrocarbon of Incorporation of Tritiated Cytidine into Mouse Epidermal Cells. Nature 203, 521–523 (1964). https://doi.org/10.1038/203521a0
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DOI: https://doi.org/10.1038/203521a0
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