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Polymorphism of Zinc-α2-Human Glycoprotein

Abstract

GENETICALLY determined variants of a large number of proteins, including many blood proteins, have been discovered, especially since the introduction by Smithies1 of the gel-electrophoresis technique. α1-Acid glycoprotein, one of the low-molecular-weight normal human plasma proteins, proved to be polymorphic near its isoelectric point. Pooled α1-acid glycoprotein revealed seven and, after enzymatic removal of its sialic acid, two bands2. The human β2-mucoid the molecular weight of which is similar to that of the mentioned α1-globulin showed a very similar resolution3. We report in this communication the polymorphism of a low-molecular-weight α2-glycopro-tein, zinc-α2-glycoprotein4.

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References

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SCHMID, K., TAKAHASHI, S. Polymorphism of Zinc-α2-Human Glycoprotein. Nature 203, 407–408 (1964). https://doi.org/10.1038/203407a0

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