Abstract
GENETICALLY determined variants of a large number of proteins, including many blood proteins, have been discovered, especially since the introduction by Smithies1 of the gel-electrophoresis technique. α1-Acid glycoprotein, one of the low-molecular-weight normal human plasma proteins, proved to be polymorphic near its isoelectric point. Pooled α1-acid glycoprotein revealed seven and, after enzymatic removal of its sialic acid, two bands2. The human β2-mucoid the molecular weight of which is similar to that of the mentioned α1-globulin showed a very similar resolution3. We report in this communication the polymorphism of a low-molecular-weight α2-glycopro-tein, zinc-α2-glycoprotein4.
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References
Smithies, O., Adv. Protein Chem., 14, 1 (1959).
Schmid, K., and Binette, J. P., Nature, 190, 630 (1961).
Schultze, H. E., Heide, K., and Haupt, H., Naturwiss., 48, 719 (1961).
Bürgi, W., and Schmid, K., J. Biol. Chem., 236, 1066 (1961).
Schmid, K., and Bürgi, W., Biochim. Biophys. Acta, 47, 440 (1961).
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Blumberg, B. S., and Warren, L., Biochim. Biophys. Acta, 50, 90 (1961).
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SCHMID, K., TAKAHASHI, S. Polymorphism of Zinc-α2-Human Glycoprotein. Nature 203, 407–408 (1964). https://doi.org/10.1038/203407a0
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DOI: https://doi.org/10.1038/203407a0
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