Abstract
A HIGH incidence of renal tumours in rats has been induced in this laboratory by a short and intensive feeding with dimethylnitrosamine (DMN), that is, 100 or 200 parts per million (p.p.m.) in the diet for 4 weeks or 1 week respectively1. Longer exposures than these to such doses will produce fatal liver necrosis. Renal tumours were also observed in about 20 to 30 per cent of rats surviving a single intraperitoneal injection of 30 or more mg/kg of DMN1. The carcinogenic action of a single administration of DMN has recently been confirmed in another laboratory on rats of a different strain and tumours of the kidney were induced by single doses of diethylnitrosamine2. Renal tumours, as well as lung tumours, have been observed by Zak et al.3 in Sprague–Dawley rats given a diet containing 125 p.p.m. of DMN for more than 80 days.
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TERRACINI, B., MAGEE, P. Renal Tumours in Rats following Injection of Dimethylnitrosamine at Birth. Nature 202, 502–503 (1964). https://doi.org/10.1038/202502a0
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DOI: https://doi.org/10.1038/202502a0
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