Abstract
INVESTIGATIONS with several virus systems have indicated clearly that only one strand of the double-stranded DNA helix carries the coding for protein synthesis1–4. To distinguish this strand it might be called the ‘coding’ strand since in addition to priming the formation of complementary DNA, its complementary RNA copy contains the information for protein synthesis. The second strand might be called the ‘replicating’ strand, meaning that it serves only to prime the formation of complementary DNA with DNA polymerase.
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References
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ROTH, J. Biological Information in a Single Strand of Deoxyribonucleic Acid. Nature 202, 182–183 (1964). https://doi.org/10.1038/202182a0
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DOI: https://doi.org/10.1038/202182a0
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