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Effect of Copper Loading on Uptake and Excretion of Copper-64 by Rat Liver

Abstract

PROLONGED administration of copper to rats results in an increase of liver copper content1–4, indicating that the liver is not able to eliminate the administered copper completely. The mechanism of this retention of copper is not known, and it seemed of interest to investigate the effect of copper loading on the handling of tracer doses of copper-64 by the liver.

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SCHEUER, P., BARKA, T. Effect of Copper Loading on Uptake and Excretion of Copper-64 by Rat Liver. Nature 201, 1135–1136 (1964). https://doi.org/10.1038/2011135a0

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