Abstract
ALTHOUGH mammalian brain tissue can synthesize acetylcholine (ACh) in vitro1, and a substance resembling ACh can be extracted from such tissue2, the identity of this substance with ACh has been questioned3. However, it has been demonstrated recently by the methods of parallel biological assay4, and a combination of chromatographic and electrophoretic techniques4,5, that the major cholinomimetic substance extracted from the mammalian brain corresponds to ACh in both a qualitative and quantitative fashion in a number of tests. This finding has led to a comparison of the effect of a purified brain extract with that of authentic ACh on single neurones in the nervous system.
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RYALL, R., STONE, N., CURTIS, D. et al. Action of Acetylcholine extracted from Brain on Spinal Renshaw Cells. Nature 201, 1034–1035 (1964). https://doi.org/10.1038/2011034a0
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DOI: https://doi.org/10.1038/2011034a0
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