Abstract
IN their paper on sympathomimetic amines, Barger and Dale1 described the action of hordenine (the N : N-dimethyl derivative of tyramine), and showed that the quaternary derivative, hordenine methiodide (1; R′ = R″ = H), had a nicotine-like action. They also found that the trimethylammonium derivative (1; R′ = R″ = H) of dopamine had a stronger nicotine -like action, about as strong as nicotine itself.
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References
Barger, G., and Dale, H. H., J. Physiol. (Lond.), 41, 19 (1910).
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BURN, J., CUTHBERT, M. & WIEN, R. Quaternized Sympathomimetic Amines. Nature 200, 270–271 (1963). https://doi.org/10.1038/200270b0
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DOI: https://doi.org/10.1038/200270b0
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