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Anti-anaphylactic Action of Acetylsalicylate in Guinea Pig Lung

An Erratum to this article was published on 09 November 1963

Abstract

HISTAMINE, plasma kinins and slow-reacting substance (SRS-A) are released or produced in anaphylaxis1–3. In the guinea pig, intravenous injection of each of these substances causes bronchoconstriction4,5. The bronchoconstriction induced by kinins or SRS-A is readily prevented by acetylsalicylic acid or its salts (acetylsalicylate), but not by mepyramine; whereas that induced by histamine is prevented by mepyramine, but not by acetylsalicylate4–7. These facts suggest that both drugs together might protect guinea pigs against anaphylactic bronchoconstriction and that each drug separately might have a partial protective action. Although mepyramine has been shown to exert some protection6,8, previous attempts have failed to show that acetylsalicylate6 or salicylate9,10 were effective. Stresemann11 has recently reported that amidopyrine, phenazone and phenylbutazone partially protected guinea pigs against an aerosol of antigen; but large doses of drug were needed and he considered the effect non-specific. The present communication describes a fuller investigation of the action of acetylsalicylate against anaphylactic bronchoconstriction in the guinea pig.

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COLLIER, H., HAMMOND, A. & WHITELEY, B. Anti-anaphylactic Action of Acetylsalicylate in Guinea Pig Lung. Nature 200, 176–178 (1963). https://doi.org/10.1038/200176b0

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