Abstract
AN earlier communication1 concerned with the structures of ferrichrome and ferrichrome A left open the particular arrangement of the 3 residues of neutral amino-acids and 3 residues of δ-N-hydroxyornithine2 within the cyclic hexapeptide moiety of the naturally occurring ferric trihydroxamates. The peptide portion of ferrichrome contains 3 residues each of glycine and δ-N-hydroxyornithine while, in ferrichrome A, 2 of the 3 glycine residues are replaced by serine residues. In the present report we propose that the sequence for ferrichrome is cyclo-triglcyl-tri-δ-N-hydroxyonithyl while that for ferrichrome A is most probably cyclo-diseryl-glycyl-tri-δ-N-hydroxyornithyl.
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References
Emery, T., and Neilands, J. B., J. Amer. Chem. Soc., 83, 1626 (1961).
Rogers, S., and Neilands, J. B., Biochemistry, 2, 6 (1963).
Gipson, R. M., Pettit, F. H., Skinner, C. G., and Shive, W., J. Org. Chem., 28, 1425 (1963).
Mikeš, O., and Turková, J. (personal communication).
Spackman, D. H., Stein, W. H., and Moore, S., Anal. Chem., 30, 1190 (1958).
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ROGERS, S., WARREN, R. & NEILANDS, J. Amino-acid Sequences within the Ferrichrome Cyclic Hexapeptides. Nature 200, 167 (1963). https://doi.org/10.1038/200167a0
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DOI: https://doi.org/10.1038/200167a0
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