Abstract
EVER since the last century when Alexander Schmidt introduced the idea that the clotting of blood can be due to a fibrin ferment which he named thrombin, efforts have been made to understand how this enzyme arises from prothrombin. He already had the view that lipids are concerned, but never knew about Ac-globulin, which is a plasma constituent important for the generation of thrombin activity in association with lipids.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Seegers, W. H., Levine, W. G., and Shepard, R. S., Canad. J. Biochem. Physiol., 36, 603 (1958).
Kowarzyk, H., and Marciniak, E., Polski Tygodnik Lekarski, 16, 1641 (1961).
Marciniak, E., and Seegers, W. H., Canad. J. Biochem. Physiol., 40, 597 (1962).
Seegers, W. H., Cole, E. R., Harmison, C. R., and Marciniak, E., Canad. J. Biochem. Physiol., 41, 1047 (1963).
Seegers, W. H., Rec. Chem. Prog., 13, 143 (1952).
Seegers, W. H., Cole, E. R., and Marciniak, E., Thromb. Diath. Hœm., 7, 239 (1962).
Cole, E. R., Marciniak, E., and Seegers, W. H., Thromb. Diath. Hœm., 8, 434 (1962).
Ware, A. G., Murphy, R. C., and Seegers, W. H., Science, 106, 618 (1947).
Landaburu, R. H., and Seegers, W. H., Amer. J. Physiol., 193, 169 (1958).
Seegers, W. H., Prothrombin (Harvard Univ. Press, Cambridge, Mass., 1962).
Ware, A. G., and Seegers, W. H., J. Biol. Chem., 172, 699 (1948).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SEEGERS, W., COLE, E., AOKI, N. et al. Fundamental Function of Ac-globulin and Lipid in Blood Clotting. Nature 200, 1014–1015 (1963). https://doi.org/10.1038/2001014a0
Issue Date:
DOI: https://doi.org/10.1038/2001014a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
