Abstract
MOST of the radiobiological protection substances reported in the past are effective when they are administered during, or just before, irradiation, or when given in seriously toxic doses. Therefore, they are of little value for practical purposes except such a case as will be expected preliminarily in medical irradiation. The ideal radiobiological protection substance should give longer tolerance to radiation as in the case of an ideal agent against infectious disease—vaccine. Betz1 and Cronkite et al.2 have reported the change of the effects of whole-body pre-X-irradiation resulted in a reduced mortality rate in mice. But this previous irradiation should be avoided in consideration of cumulative genetic effect of radiation. We have adopted the inhalation of ozone of relatively low concentration as a previously administrative agent for radiation protection. Ozone is well known as radiomimetic3, but neither a leucopenia nor the existence of ozone was determined in the blood of the mice exposed in a relatively low concentration of ozone.
Similar content being viewed by others
Article PDF
References
Betz, H., C.R. Soc. Biol., 144, 1439 (1950).
Cronkite, E. P., et al., Proc. Soc. Exp. Biol. Med., 73, 184 (1950).
Brinkman, R., and Lamberts, H. B., Nature, 181, 1202 (1958).
Stokinger, H. E., and Scheel, L. D., Amer. Med. Assoc. Arch. Environmental Health, 4, 327 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HATTORI, K., KATO, N., KINOSHITA, M. et al. Protective Effect of Ozone in Mice against Whole-body X-irradiation. Nature 198, 1220 (1963). https://doi.org/10.1038/1981220a0
Issue Date:
DOI: https://doi.org/10.1038/1981220a0
This article is cited by
-
Renal antioxidant enzymes: Their regulation and function
Kidney International (1994)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.