Abstract
SEVERAL attempts to isolate purified encephalitogenic factor(s) capable of producing experimental ‘allergic’ encephalomyelitis (with Freund's adjuvants) have been reported1–5. Recently, Kies, Gordon, Laatsch and Alvord6 were successful in obtaining a derivative from guinea pig brain active in doses of 1–2 µg; and Robertson et al.7 obtained a preparation which showed “high … activity even at five gamma doses”.
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Kies, M. W., Alvord, E. C., and Roboz, E., J. Neurochem., 2, 261 (1958).
Roboz-Einstein, E., Robertson, D. M., and DiCaprio, J., Fed. Proc., 19, 1 (1960).
Kies, M. W., Murphy, J. B., and Alvord, E. C., Chemical Pathology of the Nervous System, edit. by Folch-Pi, J., 197 (Pergamon Press, New York. 1961).
Laatsch, R. H., Kies, M. W., Gordon, S., and Alvord, E. C., J. Exp. Med., 115, 4 (1962).
Roboz, E., Henderson, N., and Kies, M. W., J. Neurochem., 2, 254 (1958).
Kies, M., Gordon, S., Laatsch, R. H., and Alvord, E. C., Proc. Fourth Intern. Cong. Neuropath., 1, 20 (Georg Thieme Verlag, Stuttgart, 1961).
Robertson, D. M., Blight, R., and Lumsden, C. E., Nature, 196, 1005 (1962).
Caspary, E. A., Biochem. J., 84, 47, P (1962).
Caspary, E. A., and Field, E. J., Deutsche Z. Nervenheilk (in the press).
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CASPARY, E., FIELD, E. Encephalitogenic Factor in Experimental ‘Allergic’ Encephalomyelitis. Nature 197, 1218 (1963). https://doi.org/10.1038/1971218a0
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DOI: https://doi.org/10.1038/1971218a0
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