Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Cheek Pouch of the Syrian Hamster and Immunity to Heterotransplantation of a Murine Leukæmia

Nature volume 197, pages 1021–1023 (1963)Cite this article

Abstract

THE consistent failure of AK–4 leukæmia of the AKR mouse to grow in the cheek pouches of normal or cortisone-treated hamsters is in contrast to the routine hetero-transplantability of certain other murine leukæmias1,2. Other investigations in these laboratories have demonstrated the accelerated rejection of second-set AK-4: hetero-grafts in the cheek pouch, suggesting that the primary inability of the neoplasm to grow in hamster pouches is attributable to an immune response on the part of the host3. Since a method for successfully transplanting AK–4: in lethally irradiated hamsters has been devised4, in which cell suspensions of the leukæmia are introduced intravenously by orbital puncture, the hamster's acquisition of immunity to the neoplasm may be examined not only with the leukæmia undergoing rejection3, but also with the leukæmia actively growing.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Handler, A. H., Transplant. Bull., 3, 153 (1956).

    Google Scholar 

  2. Handler, A. H., Adams, R. A., and Farber, S., Acta Union Intern. Contre le Cancer, 16, 1175 (1960).

    CAS  Google Scholar 

  3. Adams, R. A. (to be published).

  4. Adams, R. A., and Handler, A. H., Fed. Proc., 18, 1833 (1959).

    Google Scholar 

  5. Eagle, H., Proc. Soc. Exp. Biol. and Med., 89, 362 (1955).

    Article  CAS  Google Scholar 

  6. Foley, G. E., Handler, A. H., Adams, R. A., and Craig, J. M., Symp. Anal. Cellculture, National Cancer Institute, Mon. No. 7, 173 (1962).

  7. Billingham, R. E., Ferrigan, L. W., and Silvers, W. K., Science, 142, 1488 (1960).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Children's Cancer Research Foundation and Department of Pathology, Harvard Medical School at the Children's Hospital, Boston, Mass.

    RICHARD A. ADAMS

Authors
  1. RICHARD A. ADAMS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

ADAMS, R. Cheek Pouch of the Syrian Hamster and Immunity to Heterotransplantation of a Murine Leukæmia. Nature 197, 1021–1023 (1963). https://doi.org/10.1038/1971021b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1971021b0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing