Abstract
METHYLPENTYNOL, a central nervous system depressant, is a tertiary carbinol. Previous methods for its estimation consist of distilling the drug which is volatile out of the tissue or fluid sample into ammoniacal silver nitrate. By virtue of its acetylinic bond methylpentynol combines quantitatively with the silver to form a precipitate. Since two moles of silver react with each acetylinic group1 the quantity of methylpentynol present can be detected by either colorimetric determination of the amount of silver in the precipitate2 or by back-titration of the uncombined silver in the supernatant with potassium thiocyanate3, recovery curves for methylpentynol being obtained by the addition of known quantities of methylpentynol to ammoniacal silver and titration with potassium thiocyanate. The former method is sensitive to 1.0 mg and the latter to 0.1 mg methylpentynol.
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References
Siggia, S., Quantitative Organic Analysis via Functional Groups, 49 (John Wiley and Sons, New York, 1949).
Perlman, P. L., and Johnson, C., J. Amer. Pharm. Assoc., Sci. Ed., 41, 13 (1952).
Marley, E., and Vane, J. R., Brit. J. Pharmacol., 13, 364 (1958).
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ADAMS, B., ALLEN, D. & MARLEY, E. Estimation of Methylpentynol. Nature 197, 83–84 (1963). https://doi.org/10.1038/197083a0
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DOI: https://doi.org/10.1038/197083a0
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