Abstract
CERTAIN drugs, when administered to individuals deficient in erythrocyte glucose-6-phosphate (G-6-P) dehydrogenase, can cause hæmolytic crises. Episodes of acute hæmolytic anæmia caused by a variety of infections have been reported in enzyme-deficient individuals1. To investigate if the presence of a similar deficiency in monkeys could explain the severe hæmolysis which is a frequent feature of acute Plasmodium knowlesi infections in monkeys, quantitative estimations of erythrocyte G-6-P dehydrogenase were carried out. Fifty-eight rhesus monkeys, Macaca mulatta, of both sexes, were examined, and no evidence of dehydrogenase deficiency was found. This finding is in agreement with the recent report of Lie-Injo Luan Eng2.
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FLETCHER, K., MAEGRAITH, B. Glucose-6-Phosphate and 6-Phosphogluconate Dehydrogenase Activities in Erythrocytes of Monkeys infected with Plasmodium knowlesi. Nature 196, 1316–1318 (1962). https://doi.org/10.1038/1961316b0
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DOI: https://doi.org/10.1038/1961316b0
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