Abstract
BOLLAG1 first reported that pregnant rats given an injection of ‘Busulphan’ 5–7 days before parturition produced sterile offspring. Later, Galton and Till2 stated that “earlier in pregnancy quite large doses do not interfere with its course and the F1 and F2 generations are apparently healthy”. In view of these studies and our knowledge of the effect of ‘Busulphan’ on the adult rat testis3–5, it was decided to reinvestigate the sensitivity of the proliferating cell systems of the fœtal gonad during development.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bollag, W., Schweiz. med. Wschr., 84, 393 (1954).
Galton, D. A. G., and Till, M., Adv. Cancer Res., 4, 83 (1956).
Craig, A. W., Fox, B. W., and Jackson, H., Nature, 181, 353 (1958).
Jackson, H., Fox, B. W., and Craig, A. W., Brit. J. Pharmacol., 14, 149 (1959).
Jackson, H., Fox, B. W., and Craig, A. W., J. Reprod. Fertil., 2, 447 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HEMSWORTH, B., JACKSON, H. Effect of ‘Busulphan’ on the Fœtal Gonad. Nature 195, 816–817 (1962). https://doi.org/10.1038/195816a0
Issue Date:
DOI: https://doi.org/10.1038/195816a0
This article is cited by
-
Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells
Nature Communications (2015)
-
The selective sterilizing action of myleran on the ovaries of rat fetuses
Bulletin of Experimental Biology and Medicine (1972)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
