Abstract
TRANSFER of experimental glomerulonephritis on originally healthy rats has been accomplished in this and other laboratories by means of parabiosis1,2. Transfer was observed in random-bred as well as in inbred rats, either in short-term experiments or after intervals up to 71 days between institution of nephrotoxic serum glomerulonephritis in the primarily nephritic animal, and parabiotic conjunction with the originally healthy partner3–5. Fluorescein-labelled antisera were used to exclude the involvement of the primarily injected heterologous (rabbit) antibodies in the transfer phenomenon6. From these experiments it was derived that a secondary nephritis-producing factor, appearing as a consequence of the nephrotoxic serum glomerulonephritis in the circulation of the primarily nephritic rat, was transferred to the primarily healthy animal capable of attacking the corresponding organs of the latter.
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PFEIFFER, E., MÜLLER-RUCHHOLTZ, W. & FEDERLIN, K. Transfer of Nephrotoxic Glomerulonephritis in Rats by means of White Blood Cells. Nature 195, 718 (1962). https://doi.org/10.1038/195718a0
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DOI: https://doi.org/10.1038/195718a0
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