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Antibrain Antibodies of the 19S γ-Globulin Type in Rats with Allergic Encephalomyelitis

Nature volume 194, pages 391–392 (1962)Cite this article

Abstract

IT is known that complement-fixing antibrain antibodies can be detected in rats and other animals with allergic encephalomyelitis following sensitization to nervous tissue plus Freund's adjuvant1. Although these complement-fixing antibrain antibodies fix complement with autologous brain antigen2, failure to transfer passively allergic encephalomyelitis with immune serum and the lack of correlation between antibody titre and occurrence of disease in individual animals have left the role of such antibodies undefined1,3. This communication summarizes additional studies which indicate that complement-fixing antibrain antibodies in rats appear to belong to 19S-type γ-globulins and are incapable of giving passive cutaneous anaphylaxis.

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Author notes

  1. PHILIP Y. PATERSON: Recipient of Investigatorship of the Health Research Council of New York City.

Authors and Affiliations

  1. Department of Medicine, New York University School of Medicine, New York

    S. MARTIN HARWIN & PHILIP Y. PATERSON

Authors
  1. S. MARTIN HARWIN
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  2. PHILIP Y. PATERSON
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HARWIN, S., PATERSON, P. Antibrain Antibodies of the 19S γ-Globulin Type in Rats with Allergic Encephalomyelitis. Nature 194, 391–392 (1962). https://doi.org/10.1038/194391a0

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