Abstract
SIMILAR antiphlogistic and biochemical effects of salicylate, adrenocorticotropic hormone (ACTH) and cortisol1 have stimulated interest in establishing a possible influence of salicylate on the secretion of adrenocortical hormones in man and experimental animals. Studies in dogs, guinea pigs and rats have shown a stimulatory effect of salicylate on cortisol secretion2. It has been emphasized, however, that these experiments used a dose per unit of body-weight greater than the comparable therapeutic dose in man3,4. Furthermore, an anti-rheumatic effect of salicylate has been demonstrated in a patient whose adrenocortical function had been suppressed by 9-α-fluorohydrocortisone5. In view of this conflicting evidence, the present work was designed to determine whether or not salicylate has a direct stimulatory effect on the adrenal cortex.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hallman, H. F., J. Clin. Endo. and Metab., 12, 454 (1952).
Done, A. K., Ely, R., and Kelley, V., Metab., 7, 52 (1958).
Smith, M. J. H., Ann. Rheum. Dis., 18, 298 (1959).
Batterman, R. C., Postgrad. Med., 25, 152 (1959).
Peterson, R. E., Black, R., and Bunim, J., Arthr. and Rheum., 1, 29 (1958).
McClean, A. J., Ann. Surg., 88, 985 (1928).
Hilton, J. G., Weaver, D., Muelheims, G., Glaviano, V., and Wegria, R., Amer. J. Physiol., 192, 525 (1958).
Peterson, R. E., Karrer, A., and Guerra, S., Anal. Chem., 29, 144 (1957).
Brody, B. B., Udenfriend, S., and Coburn, A., J. Pharm. and Exp. Therap., 80, 114 (1944).
Cochran, J. B., Watson, R., and Reid, J., Brit. Med. J., ii, 1411 (1950).
Van Cauwenberge, H., and Heughsem, C., Lancet, ii, 771 (1951).
Smith, M. J. H., Gray, C., and Lunnon, J., Lancet, i, 1008 (1954).
Bayliss, R. I. S., and Steinbeck, A., Lancet, i, 1010 (1954).
Herndon, R. F., Freeman, S., Wheeler, J., and Lestina, F., Amer. Med. Assoc. Arch. Int. Med., 101, 623 (1958).
Ulloa, A., Gautney, M., Holley, H., and Hill, jun., S., Amer. Med. Assoc. Int. Med., 105, 914 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CRAMPTON, R., BLACK, W., VERDESCA, A. et al. Influence of Salicylate on Cortisol Secretion in the Dog. Nature 194, 295–296 (1962). https://doi.org/10.1038/194295a0
Issue Date:
DOI: https://doi.org/10.1038/194295a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.