Abstract
IT is now well established that the parenteral administration of large doses of œstrogens to mice results in the deposition of new bone in the marrow cavities. This change is most pronounced in the long bones. Here the new bone is first laid down at both extremities on the trabeculæ of the spongiosa and then, becoming more compact, it extends along the longitudinal axis of the shaft towards the centre of the marrow cavity. Among mammals this response to œstrogens is peculiar to the mouse. It has provided us with an important method for studying the factors which influence bone formation.
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References
Gardner, W. O., and Pfeiffer, C. A., Anat. Rec., 73, 21, Supp. (1939).
Urist, M. R., Budy, A. M., and McLean, F. C., Amer. J. Bone and Joint Surgery, 32, a, 143 (1950).
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BARKER, D., CROSSLEY, J. Effect of Testosterone on Œstrogen-induced Bone Formation in Mice. Nature 194, 1088–1089 (1962). https://doi.org/10.1038/1941088a0
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DOI: https://doi.org/10.1038/1941088a0
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