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Inhibition of Kieselguhr Agglutination of Serum by Seromucoid and Pig Serum Glycoprotein Content

Abstract

IN the course of an experiment, one of us (S. S.) found incidentally that sera such as human, bovine, guinea pig, rabbit and dog agglutinate kieselguhr but pig serum does not, and the mixture of serum and kieselguhr remains homogeneous1. We are interested in the chemical mechanism involved in agglutination and in the species difference. The occurrence of agglutination is considered, at least in part, as being due to the ionic interaction between positively charged ɛ-amino groups of lysine and negatively charged kieselguhr2. The inagglutinability of pig serum remained unexplained.

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References

  1. Sato, S., Med. and Biol. (Tokyo), 42, 111 (1957).

    Google Scholar 

  2. Sato, S., Amizuka, T., and Sato, K., Seikagaku, 32, 681 (1960).

    Google Scholar 

  3. Hirst, G. K., J. Exp. Med., 87, 315 (1948); 89, 223 (1949). Stuhlberg, C. S., Schapira, R., Robinson, A. R., and Basinski, D. H., Proc. Soc. Exp. Biol. Med., 76, 704 (1951).

    Article  CAS  Google Scholar 

  4. Lineweaver, H., and Murray, C. W., J. Biol. Chem., 171, 565 (1947).

    CAS  PubMed  Google Scholar 

  5. Greenspan, E. M., Science, 114, 395 (1951).

    Article  ADS  CAS  Google Scholar 

  6. Sato, S., Funakoshi, H., and Amizuka, T., Med. and Biol. (Tokyo), 50, 42 (1959).

    Google Scholar 

  7. Winzler, R. J., Methods of Biochemical Analysis, 2, 279 (1955).

    Google Scholar 

  8. Werner, I., and Odin, L., Acta Soc. Med. Upsaliensis, 57, 230 (1952).

    CAS  Google Scholar 

  9. Blix, G., Z. Physiol. Chem., 240, 43 (1936).

    Article  CAS  Google Scholar 

  10. Yamashina, I., Acta Chem. Scand., 10, 1666 (1956). Odin, L., and Werner, I., Acta Soc. Med. Upsaliensis, 57, 227 (1952).

    Article  CAS  Google Scholar 

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SATO, S., AMIZUKA, T. & SATO, K. Inhibition of Kieselguhr Agglutination of Serum by Seromucoid and Pig Serum Glycoprotein Content. Nature 193, 779–780 (1962). https://doi.org/10.1038/193779a0

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