Abstract
THE following experimental results have been reported by our colleagues on the potentiation of epinephrine action by various substances, clarifying part of its mechanism : (1) The potentiation of epinephrine action on vasoconstriction by certain amino-acids was attributed to a reaction in which the oxidized form of epinephrine gave rise to the oxidative de-amination of amino-acids and was reduced by the generated hydrogen1,2. (2) The epinephrine potentiation in the presence of histidine resulted from its combination with cupric ion in the tissues, which was considered as one of the oxidizing catalysts of epinephrine3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Yamamoto, I., Osaka Daigaku Igaku Zassi, 2 (8), 15 (1948).
Imaizumi, R., and Yoshida, H., Med. J. Osaka Univ., 4, (I), 115 (1953).
Matsumoto, H., Osaka Daigaku Igaku Zassi, 10, 349 (1958).
Axelrod, J., and Tomchick, R., J. Biol. Chem., 233, 702 (1958).
Imaizumi, R., et al., Jap. J. Pharmacol., 8, 87 (1959).
Yoshida, H., and Noda, T., Osaku Daigaku Igaku Zassi, 6 (3), 193 (1954).
Ito, M., Osaka Daigaku Igaku Zassi, 9, 555 (1957).
Unoki, A., Osaka Daigaku Igaku Zassi, 11, 1547 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
IMAIZUMI, R., HASHIMOTO, Y. & OKA, M. Potentiation of Epinephrine Action. Nature 191, 186–187 (1961). https://doi.org/10.1038/191186a0
Issue Date:
DOI: https://doi.org/10.1038/191186a0
This article is cited by
-
Orientierende Übersicht
Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie (1966)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.