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Mutation in Tobacco Mosaic Virus induced by a New Carcinogen, 4-Nitroquinolme N-Oxide

Nature volume 190, pages 833–834 (1961)Cite this article

Abstract

SEVERAL reports on the mechanism of mutation induced by nitrous acid in tobacco mosaic virus (TMV) phages T 2, T 4, ϕ × 174, and in transforming deoxyribonucleic acid (DNA), have been published. These indicate that, with nitrous acid treatment, inactivation and mutation occur at the same time, and therefore either may be due to a single chemical alteration in nucleic acid.

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Authors and Affiliations

  1. Cancer Institute, Japanese Foundation for Cancer Research, Tokyo

    HIDEYA ENDO

  2. Department of Chemistry, Faculty of Science, Ochanomizu University, Tokyo

    AKIYOSHI WADA

  3. Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo,

    KIN-ICHIRO MIURA

  4. Hatano Tobacco Experiment Station, Hatano, Kanagawa-ken

    ZYUN HIDAKA & CHUJI HIRUKI

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  1. HIDEYA ENDO
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  2. AKIYOSHI WADA
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  3. KIN-ICHIRO MIURA
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  4. ZYUN HIDAKA
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  5. CHUJI HIRUKI
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ENDO, H., WADA, A., MIURA, KI. et al. Mutation in Tobacco Mosaic Virus induced by a New Carcinogen, 4-Nitroquinolme N-Oxide. Nature 190, 833–834 (1961). https://doi.org/10.1038/190833a0

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