Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Applicability of Hydroxocobalamin as a Long-acting Vitamin B12

Nature volume 189, pages 138–140 (1961)Cite this article

Abstract

THE main difficulty in the treatment of vitamin B12 deficiencies has been that small doses of cyanocobalamin are inadequate to replenish the body's depleted stores and that most of the large parenteral doses are eliminated in the urine within the first 12 hr.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Beard, M. F., and LaBaw, E., Proc. Internat. Soc. Hematology, Sixth Congress, Boston, 426 (abstr.) (1956).

  2. Arnold, A., Berbian, D. A., and Sobell, S. D., Amer. Pract. Digest of Treatment, 9, 1835 (1958). O'Connor, J. S., Davis, R. L., Langworthy, O. R., and Chow, B. F., Fed. Proc., 17, 528 (1958).

    CAS  Google Scholar 

  3. Glass, G. B. J., Skeggs, H. R., Lee, D. H., Jones, E. L., and Hardy, W. W., Blood (submitted for publication).

  4. Lichtman, H., Watson, J., Ginsberg, V., Pierce, J. V., Stokstad, E. L. R., and Jukes, T. H., Proc. Soc. Exp. Biol. and Med., 72, 643 (1949). Schilling, R. F., Harris, J. W., and Castle, W. B., Blood, 6, 228 (1951).

    Article  CAS  Google Scholar 

  5. Skeggs, H. R., Nepple, K. M., Valentik, K. A., Huff, J. W., and Wright, L. D., J. Biol. Chem., 184, 211 (1950).

    CAS  PubMed  Google Scholar 

  6. Glass, G. B. J., Boyd, L. J., and Gellin, G. A., Blood, 10, 95 (1955).

    CAS  PubMed  Google Scholar 

  7. Miller, A., and Sullivan, J. F., J. Clin. Invest., 37, 917 (1958). Bauriedel, W. R., Picken, jun., J. C., and Underkofler, L. A., Proc. Soc. Exp. Biol. Med., 91, 377 (1956).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, New York Medical College, Bird S. Coler Memorial Hospital, New York

    G. B. J. GLASS, H. R. SKEGGS, D. H. LEE, E. L. JONES & W. W. HARDY

  2. Merck Sharp and Dohme Research Laboratories, Merck and Co., Inc., West Point, Pennsylvania

    G. B. J. GLASS, H. R. SKEGGS, D. H. LEE, E. L. JONES & W. W. HARDY

Authors
  1. G. B. J. GLASS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. R. SKEGGS
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. H. LEE
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. L. JONES
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. W. W. HARDY
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

GLASS, G., SKEGGS, H., LEE, D. et al. Applicability of Hydroxocobalamin as a Long-acting Vitamin B12 . Nature 189, 138–140 (1961). https://doi.org/10.1038/189138b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/189138b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing