Abstract
IT has been shown that cocaine specifically inhibits the synthesis of citrate in yeast1 and in animal tissues2, and that other local anæsthetics possess a similar specificity of action in blocking cellular respiration3. An enzyme, malate synthetase, which catalyses the synthesis of malate from acetate and glyoxylate in a manner analogous to the formation of citrate from acetate and oxaloacetate, has since been discovered4 and has been shown to participate in some micro-organisms in a modified citric acid cycle which has been described as the glyoxylate cycle5.
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KALYANPUR, S., WALSH, E. Malic Acid Synthesis in Escherichia coli and its Inhibition by Cocaine. Nature 188, 939–940 (1960). https://doi.org/10.1038/188939a0
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DOI: https://doi.org/10.1038/188939a0
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