Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Isolation of Purified Trichophytin

Nature volume 188, pages 232–233 (1960)Cite this article

Abstract

COMMERCIAL, preparations of trichophytin1 are generally aqueous extracts of the fungal mycelium (for example, Trichophyton mentagrophytes) together with a proportion of the culture medium. They thus contain a variety of substances which are not specific to trichophytin sensitivity and which may contribute in a variety of ways to the production of the skin reaction. In order to limit this non-specific response and to define the significance of the trichophytin reaction, an attempt has been made to isolate the antigenic material in a purified form and to obtain preliminary data as to its constitution.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Bloch, B., Labouchere, A., and Schaaf, F., Arch. f. Derm. u. Syph., 148, 413 (1924).

    Article  Google Scholar 

  2. Krebs, H. A., Z. physiol. Chem., 217, 191 (1933).

    Article  CAS  Google Scholar 

  3. Lunt, E., and Sutcliffe, D., Biochem. J., 55, 122 (1953).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

    CAS  PubMed  Google Scholar 

  5. Barker, S. A., Stacey, M., and Zweifel, G., Chem. and Indust., 330 (1957).

  6. Nelson, N., J. Biol. Chem., 153, 375 (1944).

    CAS  Google Scholar 

  7. Somogyi, M., J. Biol. Chem., 195, 19 (1952).

    CAS  Google Scholar 

  8. Elson, L. E., and Morgan, W. T. J., Biochem. J., 27, 1824 (1933).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Ceriotti, G., J. Biol. Chem., 198, 297 (1952).

    CAS  PubMed  Google Scholar 

  10. Morgan, W. T. J., Biochem. J., 31, 3003 (1937).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chemistry Department, The University, Edgbaston, Birmingham, 15

    S. A. BARKER

  2. Medical Research Council Unit for Research on the Experimental Pathology of the Skin, The Medical School, Birmingham, 15

    M. D. TROTTER

Authors
  1. S. A. BARKER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. D. TROTTER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BARKER, S., TROTTER, M. Isolation of Purified Trichophytin. Nature 188, 232–233 (1960). https://doi.org/10.1038/188232b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/188232b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing