Abstract
SOME of the enzymes of bovine spleen have been studied in detail and classified as cathepsin A, B and C according to their specificity for certain synthetic peptides1. Examination of the action of rabbit spleen extracts on human serum albumin has shown the existence of a proteolytic activity having an optimal pH at 3.0–3.5 (ref. 2). It was shown that this activity was not due to an enzyme analogous with cathepsin B or C but could have been due to a cathepsin A (ref. 3). Recently we have demonstrated that this activity was due to a single protease which we have purified by chromatography on modified cellulose4.
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References
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WEBB, T., LAPRESLE, C. Action on Some Synthetic Peptides of a Protease from Rabbit Spleen. Nature 188, 66–67 (1960). https://doi.org/10.1038/188066a0
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DOI: https://doi.org/10.1038/188066a0
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