Abstract
THE irreversibility and permanence of the basic defects in ‘inborn errors of metabolism’ have been regarded hitherto as essential pre-requisites of the condition as defined by Garrod1. The question is whether in the light of the following observations this aspect of Garrod's concept can yet be universally maintained.
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References
Garrod, A. E., Lancet, ii, 142 (1908).
Hutchison, J. H., and McGirr, E. M., J. Clin. Endocrinol. and Met., 14, 869 (1954).
Zondek, H., Leszynsky, H. E., and Zondek, G. W., Acta Endocrinol., 29, 47 (1958).
Zondek, H., Leszynsky, H. E., and Zondek, G. W., Brit. Med. J., i, 340 (1959).
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ZONDEK, H., LESZYNSKY, H. & STEIN, J. Reversibility of an Inherited Metabolic Block (Inborn Error of Metabolism). Nature 187, 515–516 (1960). https://doi.org/10.1038/187515a0
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DOI: https://doi.org/10.1038/187515a0
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