Abstract
BOVINE γ-globulin has been shown to be a mixture of molecules having N-terminal amino-acids, aspartic acid, glutamic acid, serine, alanine and valine with a total of less than 1 mole/mole of γ-globulin1. A partial fractionation was achieved by partition chromatography of γ-globulin ; the molecules with N-terminal aspartic acid, serine and alanine were concentrated in the faster running fractions, but valine, the principal N-terminal acid, was present in all the fractions2. Glutamic acid was present in only trace amounts in all the fractions.
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References
McFadden, M. L., and Smith, E. L., J. Amer. Chem. Soc., 75, 2784 (1953).
Porter, R. R., and Press, E. M., Biochem. J., 66, 600 (1957).
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PRESS, E., PORTER, R. N-Terminal Amino-Acids of Bovine Antibody. Nature 187, 59–60 (1960). https://doi.org/10.1038/187059b0
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DOI: https://doi.org/10.1038/187059b0
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