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Condensation Product of Ethylenediamine with Noradrenaline or 3,4-Dihydroxymandelic Acid

Nature volume 186, pages 310–311 (1960)Cite this article

Abstract

IT was found that the condensation reaction of ethylenediamine with adrenaline gave the main condensation product of noradrenaline as one of its by-products1. From this result, it was supposed that the side-chain of these two catechol amines could be destroyed during the condensation reaction and that the structure of the main condensation product of noradrenaline might be simpler than that of adrenaline. To investigate the structure of the main condensation product of noradrenaline, we examined further the condensation products of ethylenediamine with catechol and its derivatives which have a simpler structure than adrenaline or noradrenaline. For this purpose, 3,4-dihydroxymandelic acid (kindly provided by Dr. M. D. Armstrong) and catechol were used.

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Authors and Affiliations

  1. Department of Biochemistry,

    KUNIO YAGI

  2. Department of Neuropsychiatry,

    TOSHIHARU NAGATSU

  3. Department of Anatomy, School of Medicine, Nagoya University, Nagoya

    IKUKO NAGATSU

Authors
  1. KUNIO YAGI
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  2. TOSHIHARU NAGATSU
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  3. IKUKO NAGATSU
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YAGI, K., NAGATSU, T. & NAGATSU, I. Condensation Product of Ethylenediamine with Noradrenaline or 3,4-Dihydroxymandelic Acid. Nature 186, 310–311 (1960). https://doi.org/10.1038/186310a0

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  • DOI: https://doi.org/10.1038/186310a0

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