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Staphylocoagulase Inhibition by Pooled Human Gamma-Globulin

Nature volume 184, pages 1665–1666 (1959)Cite this article

Abstract

POOLED normal human gamma-globulin, alone or in combination with antibiotics, has been found to exert marked therapeutic activity in Staphylococcus aureus infections1–6. In seeking to understand the mechanism of this protection, it was decided to investigate the effect of gamma-globulin on staphylococcal coagulases, perhaps among the most important factors in the virulence of the organism uncovered to date7. Staphylococci form two types of coagulase, bound and free8,9 which differ in occurrence, mode of action and antigenic patterns but may both be involved in pathogenesis. Evidence has been presented that there are different antigenic varieties of free coagulase associated with the three bacteriophage groups and the two specific types10, 3A and 42E but that bound coagulase of the various staphylococcal types may be antigenically homogeneous9.

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Authors and Affiliations

  1. Department of Microbiology, University of Miami School of Medicine, Coral Gables, Florida

    MURRAY M. STREITFELD, BENNETT SALLMAN & SEYMOUR M. SHOELSON

  2. Variety Research Foundation, Miami, Florida

    MURRAY M. STREITFELD, BENNETT SALLMAN & SEYMOUR M. SHOELSON

Authors
  1. MURRAY M. STREITFELD
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  2. BENNETT SALLMAN
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  3. SEYMOUR M. SHOELSON
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STREITFELD, M., SALLMAN, B. & SHOELSON, S. Staphylocoagulase Inhibition by Pooled Human Gamma-Globulin. Nature 184, 1665–1666 (1959). https://doi.org/10.1038/1841665a0

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  • DOI: https://doi.org/10.1038/1841665a0

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