Abstract
IN the course of an investigation of the immune response of rabbits exposed to a low environmental temperature (− 15° C.) it was noted that the decay-rate of passively administered homologous antibody was increased1. Reference has been made to the fact that thyroxin-treated rabbits also exhibit an increase in passive antibody decay2. The fact that an animal metabolizes protein more rapidly under conditions of cold stress or when treated with thyroxine leads one, a priori, to consider more closely the influence of the thyroid on the immune response under cold stress. The following preliminary investigation was therefore undertaken to determine the effect of surgical thyroidectomy on the rate of decay of passively administered homologous antibody.
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References
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TRAPANI, I., LEIN, A. & CAMPBELL, D. Passive Antibody Decay in Thyroidectomized Rabbits. Nature 183, 982–983 (1959). https://doi.org/10.1038/183982a0
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DOI: https://doi.org/10.1038/183982a0
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