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A Possible Negative Feedback Phenomenon controlling Formation of Alkaline Phosphomonoesterase in Escherichia coli

Abstract

WE have already reported1 that in a phosphate-deficient medium the amount of ribonucleic acid in E. coli decreased remarkably, while there was an appreciable increase of deoxyribonucleic acid, protein and viable cell numbers. At the same time we also studied activities of some enzymes presumed to be related to the degradation of ribonucleic acid, for example, ribonuclease phosphodiesterase and phosphomonoesterase, and found a marked increase in that of phosphomonoesterase. This communication is concerned with this formation of phosphomonoesterase in E. coli.

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References

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HORIUCHI, T., HORIUCHI, S. & MIZUNO, D. A Possible Negative Feedback Phenomenon controlling Formation of Alkaline Phosphomonoesterase in Escherichia coli . Nature 183, 1529–1530 (1959). https://doi.org/10.1038/1831529b0

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