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Reserpine Derivatives with Specific Hypotensive or Sedative Activity

Nature volume 183, pages 1273–1274 (1959)Cite this article

Abstract

RECENTLY it has been reported, by Ciba Laboratories1,2, that two reserpine analogues show more specific effects than reserpine. Methyl-18-O(3-NN-dimethylaminobenzoyl)reserpate (or SU 5171) exhibits sedative activity, while carbethoxysyringoyl-methylreserpate (syrosingopine or SU 3118) is effective in decreasing blood tension (see formulæ).

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References

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  2. Plummer, A. J., Barrett, W. E., Maxwell, R. A., Finocchio, D., Lucas, R. A., and Rutledge, E., Abstracts Fall Meeting Amer. Pharm. Soc., Arbor (Mien.), 27 (1958).

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Authors and Affiliations

  1. Institute of Pharmacology, University of Milan,

    S. GARATTINI, A. MORTARI, A. VALSECCHI & L. VALZELLI

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  1. S. GARATTINI
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  2. A. MORTARI
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  3. A. VALSECCHI
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  4. L. VALZELLI
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GARATTINI, S., MORTARI, A., VALSECCHI, A. et al. Reserpine Derivatives with Specific Hypotensive or Sedative Activity. Nature 183, 1273–1274 (1959). https://doi.org/10.1038/1831273a0

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