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Relationship of Serological Reactivity to Antibody Molecular Weight

Nature volume 182, pages 1100–1101 (1958)Cite this article

Abstract

IN recent years information has been obtained concerning the molecular weight of antibody in relation to specific serological reactivity. Deutsch and Chan1 found that human A and B isoagglutinins have molecular weight near 1,000,000. Paic2 reported that rabbit anti-sheep hæmolysin had a minimum molecular weight of 420,000. More recently, Talmage et al. 3 found that the hæmolytic activity of rabbit anti-sheep hæmolysin was associated with antibodies of two distinct molecular weights. The bulk of the hæmolytic activity was associated with a high molecular weight antibody of greater hæmolytic efficiency and in addition a low molecular weight antibody of lower hæmolytic efficiency. Johnson et al. 4 reported that rabbit anti-human hæmolysin, in contrast to rabbit anti-sheep hæmolysin, has a molecular weight in the region of 160,000. We observed5 that human anti-A and rabbit anti-human hæmolysin had the same complement-fixing capacity (the amount of complement capable of being fixed), while rabbit anti-sheep hæmolysin had a complement-fixing capacity 3–4 times lower.

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References

  1. Deutseh, H. F., and Chan, P. C. Y., Fed. Proc., 17, 210 (1958).

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  2. Paic, M., Bull. Soc. Chim. Biol., 21, 412 (1939).

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  3. Talmage, D. W., Freter, G. G., and Taliaferro, W. H., J. Infect. Dis., 98, 300 (1956).

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  4. Johnson, A., Woernley, D., and Pressman, D., J. Immunol., 79, 234 (1957).

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  5. Goodman, H. S., J. Infect. Dis. (in the press).

  6. Goodman, H. S., J. Immunol. (in the press).

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  1. Mount Sinai Medical Research Foundation, Chicago, Illinois

    HAROLD S. GOODMAN

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  1. HAROLD S. GOODMAN
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GOODMAN, H. Relationship of Serological Reactivity to Antibody Molecular Weight. Nature 182, 1100–1101 (1958). https://doi.org/10.1038/1821100b0

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