Abstract
THIS communication describes a new trypanocide, which has been found to possess considerable potentiality as a curative and as a prophylactic drug, both in laboratory experiments and in field trials carried out in Africa during the past year.
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References
Barber, H. J., et al., J. Chem. Soc., 84 (1947); J. Soc. Chem. Indust., 82 (1950). Libman, D. D., and Slack, R., J. Chem. Soc., 2588 (1951). Davis, M., ibid., 337 (1956), 828 (1958).
Ashley, J. N., Barber, H. J., Ewins, A. J., Newbery, G., and Self, A. D. H., J. Chem. Soc., 103 (1942); for other references see Davis, M., ibid., 907 (1958).
British Provisional Patent Application No. 9217/56.
British Patent 728,457/1955; Milne, A. H., Robson, J., and Lwebandiza, T., Vet. Rec., 62, 280 (1955). Jensch, H., Arzneimitt. l Forsch., 5, 634 (1955).
British Patent 746,027, March 7, 1956. Walls, L. P., J. Chem. Soc., 3514 (1950).
British Provisional Patent Application No. 21814/56.
cf. Williamson, J., and Desowitz, R. S., Nature, 177, 1074 (1956).
de Beer, E. J., J. Pharm. Exp. Ther., 85, 1 (1945).
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WRAGG, W., WASHBOURN, K., BROWN, K. et al. Metamidium: a New Trypanocidal Drug. Nature 182, 1005–1006 (1958). https://doi.org/10.1038/1821005a0
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DOI: https://doi.org/10.1038/1821005a0
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