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Effects of Certain Compounds related to Trypan Blue on the Experimental Production of Liver Cancer

Abstract

PREVIOUS studies have shown that subcutaneous injections of trypan blue to rats fed with diets containing N,N,-dimethyl-p-(phenylazo)aniline inhibit the formation of liver tumours1,2. A further attempt to inhibit the experimental production of liver cancer was made with certain compounds related to trypan blue (sodium 3,3′-dimethyldiphenyl-4,4′-bis-azo-(2″)-8″-amino-1″-naphthol-3″,6″-disulphonate). The present communication deals with the effects of direct blue BB and semitrypan blue (see Fig. 1).

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FUJITA, K., MINE, T., ITO, T. et al. Effects of Certain Compounds related to Trypan Blue on the Experimental Production of Liver Cancer. Nature 181, 1732–1733 (1958). https://doi.org/10.1038/1811732a0

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