Abstract
HYPOGLYCIN-A, which is isolated from the fruit of Blighia sapida, causes severe hypoglycæmia and depletion of liver glycogen1,2. Leppla and Holt3 examined the hypothesis that glucagon depletion following pancreatic alpha-cell damage might be the cause of these metabolic changes. However, as they could not find any microscopical changes in the alpha cells after hypoglycin A administration, they were unable to support this hypothesis.
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References
Hassall, C. H., Reyle, K., and Feng, P. C., Nature, 173, 356 (1954).
Patrick, S. J., J. App. Physiol., 7, 140 (1954).
Leppla, W., and Holt, C. V., Arch. Exp. Path. and Pharm., 228, 166 (1956).
Gomori, G., Amer. J. Path., 15, 497 (1939).
Gomori, G., Amer. J. Clin. Path., 20, 665 (1950).
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FENG, P. Effect of Hypoglycin A on the Alpha Cells of the Pancreas. Nature 180, 855–856 (1957). https://doi.org/10.1038/180855a0
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DOI: https://doi.org/10.1038/180855a0
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